The Bladder Immunology Group (BIG)

Our laboratory is interested in host-microbiome interactions and carcinogenesis in the genitourinary tract. We use uropathogenic E. coli and Schistosoma haematobium as model pathogens. Through our research, we seek to better understand inflammation and harness its potential for human benefit. Please note that the laboratory's basic science work is on hiatus pending funding. We remain active as collaborators and in our translational and clinical research endeavors.

Besides studying the basic biology of genitourinary inflammation and infection, we are also collaborating with Professor Axel Krieger to develop novel surgical technologies. 

Urinary Tract Infections Image
Urinary Tract Infections

We are examining the in vivo mechanisms by which bacteria resist antibiotics and the host immune system.


Our overarching hypothesis on urogenital schistosomiasis is that Schistosoma haematobium eggs induce tissue-specific immune responses that result in compromised host defense and...